Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors.
نویسندگان
چکیده
A 192-member library of N,N'-disubstituted urea inhibitors was synthesized by a solid-phase method. The ureas were tested for their inhibitory activities against recombinant human soluble epoxide hydrolase. Simple carbocyclic or para/meta-substituted phenyl groups showed inhibition potencies that were equal to or greater than adamantane-based sEH inhibitors, while the presence of bulky or ionizable groups close to the urea group dramatically decreased their activities.
منابع مشابه
Design, Synthesis and Biological Activity of 4,6-disubstituted Pyridin-2(1H)-ones as Novel Inhibitors of Soluble Epoxide Hydrolase
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 16 22 شماره
صفحات -
تاریخ انتشار 2006